PLATFORM & PIPELINE
Transforming complex diagnostics into accessible point-of-care
PLATFORM & PIPELINE
Transforming complex diagnostics into accessible point-of-care
HOME DIAGNOSIS
Home Diagnosis 는 병원이나 전문 검사실이 아닌, 가정(Home) 환경에서 사용자가 직접 질병이나 건강 상태를 검사·모니터링하는 진단 방식을 의미합니다. 플로트바이오의 BLOOM 과 Cut & Dip 기술은 복잡한 임상 검체 처리 없이 고감도의 진단을 가능하게 만들어, 가정에서 쉽고 간편하게 다양한 질병을 진단할 수 있게 합니다. 플로트바이오는 모든 질병이 집에서 조기 진단되는 세상을 꿈꾸며 도전하고 있습니다.
논문 정보
Diagnosis of early-stage bladder cancer via unprocessed urine samples at the point of care
Abstract
A two-phase point-of-care diagnostic device for bladder cancer
Diagnostic kits for the optical detection of bladder cancer in urine can facilitate effective screening and surveillance. However, the heterogeneity of urine samples, owing to patients with bladder cancer often presenting with haematuria, interfere with the transduction of the optical signal. Here we describe the development and point-of-care performance of a device for the detection of bladder cancer that obviates the need for sample processing. The device leverages the enzymatic release of organogel particles carrying solvatochromic fluorophores in the presence of urinary hyaluronidases—a bladder cancer biomarker. Owing to buoyancy, the particles transfer from the urine sample into the organic phase, where the change in fluorescence can be measured via a smartphone without interference from blood proteins. In a double-blind study with 80 unprocessed urine samples from patients with bladder cancer (including samples with haematuria) or other genitourinary diseases and with 25 samples from healthy participants, our system distinguished the cancerous samples, including those with early-stage bladder cancer, with accuracies of about 90%. Obviating the need for sample pretreatment may facilitate the at-home detection of bladder cancer.
